Follows a best-selling author of a self-help book series who is secretly hiding her separation from her husband as she starts to navigate her life as a single woman in her 40s in Los Angeles. She starts to side with and take advice more from her divorced friends rather than her married ones, and it leads her to some unexpected and life-changing experiences.

《闺蜜离婚指南第三季》是一部话题性强的电视剧，人物形象迥然各异，配乐对情节有烘托作用，画面古朴雅致，该剧通过将轻松解压的剧集氛围与传统文化精髓相结合的方式，不仅使艺术创作与文化传播达到平衡，也与观众形成了良性互动。